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Simbrinza, brinzolamide/brimonidine tartrate

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Company Novartis AG
DescriptionFixed combination of brinzolamide, a carbonic anhydrase II (CAII) inhibitor, and brimonidine tartrate, a relatively selective adrenergic receptor alpha 2 (ADRA2) agonist
Molecular Target Carbonic anhydrase II (CAII) ; Adrenergic receptor alpha 2 (ADRA2)
Mechanism of ActionAdrenergic receptor alpha 2 (ADRA2) agonist; Carbonic anhydrase inhibitor
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentMarketed
Standard IndicationOcular hypertension
Indication DetailsTreat intraocular pressure in patients with glaucoma
Regulatory Designation

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