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topical omaveloxolone (ABV-RTA 408, RTA 408, topical RTA 408)

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Company Reata Pharmaceuticals Inc.
DescriptionOleanane triterpenoid that activates nuclear factor (erythroid-derived 2)-like 2 (NFE2L2; NRF2) and inhibits NF-kappa B (NF-kB)
Molecular Target Nuclear factor (erythroid-derived 2)-like 2 (NFE2L2) (NRF2) ; Nuclear factor of kappa light polypeptide gene enhancer in B cells 1 (NF-kB) (NFKB1) (p105) (p50)
Mechanism of ActionNuclear factor (erythroid-derived 2)-like 2 (NFE2L2) (NRF2) activator; NF-kappa B (NF-kB) inhibitor
Therapeutic ModalitySmall molecule

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