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basimglurant (RG7090, RO4917523)

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Company Roche
DescriptionNegative modulator of metabotropic glutamate receptor subtype 5 (mGluR5; GRM5)
Molecular Target Metabotropic glutamate receptor subtype 5 (mGluR5) (GRM5)
Mechanism of ActionMetabotropic glutamate receptor subtype 5 (mGluR5) antagonist
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentPhase II
Standard IndicationDepression
Indication DetailsAdjunctive treatment for major depressive disorder (MDD); Treat treatment-resistant depression
Regulatory Designation

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