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ProstVac, rilimogene galvacirepvec

Also known as: ProstVac-VF

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Company Bavarian Nordic A/S
DescriptionVaccine targeting PSA that also contains a Tricom triad of costimulatory molecules -- CD58 (LFA-3), intercellular adhesion molecule-1 (ICAM-1; CD54) and CD80 (B7-1)
Molecular Target Prostate-specific antigen (KLK3) (PSA)
Mechanism of ActionVaccine
Therapeutic ModalityActive immunotherapy
Latest Stage of DevelopmentPhase III
Standard IndicationProstate cancer
Indication DetailsTreat androgen-independent castration-resistant prostate cancer (CRPC); Treat castration-resistant prostate cancer (CRPC) with bone metastases; Treat hormone-dependent prostate cancer; Treat metastatic castration-resistant prostate cancer (CRPC); Treat metastatic prostate cancer; Treat non-metastatic castration-sensitive prostate cancer; Treat prostate cancer; Treat prostate cancer in hormone-naïve patients
Regulatory Designation

U.S. - Fast Track (Treat metastatic castration-resistant prostate cancer (CRPC));
U.S. - Special Protocol Assessment (Treat metastatic castration-resistant prostate cancer (CRPC))


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