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Esbriet, Pirfenidone (Pirespa) (S-7701)

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Company InterMune Inc.
DescriptionSmall molecule inhibitor of proinflammatory cytokines such as tumor necrosis factor (TNF) alpha and IL-1 beta, as well as pro-fibrotic cytokines, including platelet derived growth factor (PDGF) and transforming growth factor (TGF) beta
Molecular Target Tumor necrosis factor (TNF) alpha ; Transforming growth factor (TGF) beta 1 (TGFB1)
Mechanism of ActionMAP kinase (p38) inhibitor
Latest Stage of DevelopmentMarketed
IndicationPulmonary fibrosis
Partner

Ildong Pharmaceutical Co. Ltd.; Shionogi & Co. Ltd.
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