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Pirfenex, pirfenidone (Esbriet, Pirespa) (RG6062, S-7701)

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Company Roche
DescriptionSmall molecule inhibitor of proinflammatory cytokines and pro-fibrotic cytokines that targets p38 mitogen-activated protein kinase (p38 MAPK; MAPK14)
Molecular Target Tumor necrosis factor (TNF) alpha ; Transforming growth factor (TGF) beta 1 (TGFB1)
Mechanism of ActionMAP kinase (p38) inhibitor
Therapeutic ModalitySmall molecule

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