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nitisinone (SYN118)

Also known as: Orfadin

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Collapse Summary General Information
Company Syngenta AG
Description4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor
Molecular Target 4-hydroxyphenylpyruvate dioxygenase (HPPD)
Mechanism of Action4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentMarketed
Standard Indication Metabolic (unspecified)
Indication DetailsTreat hereditary tyrosinemia type I
Regulatory Designation
PartnerAstellas Pharma Inc.;
Swedish Orphan Biovitrum AB

 Product Details
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Collapse Summary Deals Information
Total Number of DealsTotal Deal ValueTotal Upfront CashTotal Milestone Payments

2

$131.9M

0

$725.0M


 Deals Details
DateCompanies InvolvedDeal HeadlineTotal Deal ValueTotal Upfront CashTotal Milestone

02/07/2011

$131.9M

0

0

10/18/2010

Undisclosed

Undisclosed

$725.0M

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