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oral methylnaltrexone (MNTX) (Oral Relistor) (MOA-728)

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Company Progenics Pharmaceuticals Inc.
DescriptionPeripheral mu opioid receptor (MOR) antagonist
Molecular Target Mu opioid receptor (MOR) (OPRM1)
Mechanism of ActionMu opioid receptor antagonist
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentPhase III
Standard IndicationConstipation
Indication DetailsTreat opioid-induced constipation (OIC); Treat opioid-induced constipation (OIC) in non-cancer patients with chronic pain
Regulatory Designation


Lupin Ltd.; Valeant Pharmaceuticals International Inc.

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