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T-Vec, talimogene laherparepvec (Imlygic)

Also known as: formerly OncoVEX GM-CSF

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Company Amgen Inc.
DescriptionModified herpes simplex virus type 1 (HSV-1) carrying the gene for GM-CSF
Molecular Target Granulocyte macrophage colony-stimulating factor (GM-CSF) (CSF2)
Mechanism of ActionOncolytic virus
Therapeutic ModalityActive immunotherapy
Latest Stage of DevelopmentMarketed
Standard IndicationMelanoma
Indication DetailsLocal treatment of unresectable cutaneous, subcutaneous and nodal lesions in patients with melanoma that is recurrent after initial surgery; Treat advanced melanoma; Treat melanoma; Treat metastatic melanoma
Regulatory Designation U.S. - Special Protocol Assessment (Treat metastatic melanoma);
U.S. - Standard Review (Treat metastatic melanoma);
EU - Standard Review (Treat metastatic melanoma)

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