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Fulyzaq, crofelemer (NP-303)

Also known as: CRO-ID (TRN-002)

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Company Napo Pharmaceuticals Inc.
DescriptionPurified proanthocyanidin oligomer extracted from the bark latex of the Amazonian tree Croton lechleri that acts as a partial antagonist of cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-activated chloride channel
Molecular Target Cystic fibrosis transmembrane conductance regulator (CFTR) ; Chloride channel
Mechanism of ActionCl channel antagonist; CFTR inhibitor
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentMarketed
Standard IndicationDiarrhea (infectious)
Indication DetailsTreat acute watery diarrhea; Treat chronic diarrhea associated with HIV/AIDS who use anti-retroviral drugs
Regulatory Designation

U.S. - Fast Track (Treat chronic diarrhea associated with HIV/AIDS who use anti-retroviral drugs);
U.S. - Priority Review (Treat chronic diarrhea associated with HIV/AIDS who use anti-retroviral drugs);
U.S. - Special Protocol Assessment (Treat chronic diarrhea associated with HIV/AIDS who use anti-retroviral drugs)

Partner

Luye Pharma Group Ltd.; Salix Pharmaceuticals Inc.


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