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IV Noxafil, posaconazole (MK-5592 IV)

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Company Merck & Co. Inc.
DescriptionInhibitor of P450 sterol C-14 alpha demethylase
Molecular Target Cytochrome P450 C-14 alpha demethylase (CYP51)
Mechanism of ActionCytochrome P450 C-14 alpha demethylase inhibitor
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentApproved
Standard IndicationFungal infection
Indication DetailsPrevent invasive fungal infections in severely immunocompromised patients; Treat fungal infection
Regulatory Designation U.S. - Undisclosed Review (Prevent invasive fungal infections in severely immunocompromised patients);
EU - Standard Review (Prevent invasive fungal infections in severely immunocompromised patients)
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