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MK-3682/MK-8408/MK-5172(grazoprevir) (MK-3682B)

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Company Merck & Co. Inc.
DescriptionCombination of MK-3682, a uridine nucleotide analog HCV NS5B polymerase inhibitor, MK-8408, an HCV NS5A protein inhibitor, and grazoprevir, an oral HCV NS3/4A protease inhibitor
Molecular Target HCV NS5B polymerase ; HCV NS5A protein
Mechanism of ActionViral polymerase inhibitor; HCV non-structural protein 5A inhibitor; HCV non-structural protein 5B inhibitor
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentPhase II
Standard IndicationHepatitis C virus (HCV)
Indication DetailsTreat chronic HCV genotype 1 or 3 infection
Regulatory Designation

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