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Lestaurtinib (CEP-701) (formerly KT-5555)

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Company Teva Pharmaceutical Industries Ltd.
DescriptionInhibitor of several tyrosine kinases including FMS-like tyrosine kinase 3 (FLT3) and janus kinase-2 (JAK-2)
Molecular Target FMS-like tyrosine kinase 3 (FLT3) (CD135) ; Janus kinase-2 (JAK-2)
Mechanism of ActionFMS-like tyrosine kinase 3 (FLT3) inhibitor; Janus kinase-2 (JAK-2) inhibitor
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentPhase I/II
Standard IndicationMyeloproliferative disorder
Indication DetailsTreat myelofibrosis; Treat myeloproliferative disorders (MPD)
Regulatory Designation

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