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AMG 416, ONO-5163 (formerly KAI-4169, Velcalcetide)

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Company Amgen Inc.
DescriptionPeptide calcimimetic that acts on the parathyroid gland to reduce production of parathyroid hormone (PTH)
Molecular Target Calcium sensing receptor (CaSR)
Mechanism of ActionCalcium-sensing receptor (CaSR) agonist
Therapeutic ModalityPeptide
Latest Stage of DevelopmentPhase III
Standard IndicationThyroid disease
Indication DetailsTreat secondary hyperparathyroidism (SHPT); Treat secondary hyperparathyroidism (SHPT) in patients with chronic kidney disease (CKD) receiving hemodialysis
Regulatory Designation


Ono Pharmaceutical Co. Ltd.

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