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CRLX101 (formerly IT-101)

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Company Arrowhead Research Corp.
DescriptionDual inhibitor of topoisomerase I (TOP1) and hypoxia-inducible factor 1 alpha (HIF1A; HIF1-alpha)
Molecular Target Topoisomerase I (TOP1) ; Hypoxia-inducible factor 1 alpha (HIF1A) (HIF1-alpha)
Mechanism of ActionTopoisomerase I inhibitor
Therapeutic ModalitySmall molecule

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