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alicaforsen (AP 1007)

Also known as: formerly ISIS 2302

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Company Ionis Pharmaceuticals Inc.
DescriptionAntisense inhibitor of intercellular adhesion molecule-1 (ICAM-1; CD54)
Molecular Target Intercellular adhesion molecule-1 (ICAM-1) (CD54)
Mechanism of ActionICAM-1 (CD54) inhibitor; Antisense therapy
Therapeutic ModalityNucleic acid: Linear RNA: Antisense
Latest Stage of DevelopmentPhase III
Standard IndicationInflammatory bowel disease (IBD)
Indication DetailsTreat chronic and recurrent pouchitis; Treat inflammatory bowel disease (IBD); Treat pouchitis; Treat ulcerative colitis (UC)
Regulatory Designation U.S. - Fast Track (Treat chronic and recurrent pouchitis);
U.S. - Orphan Drug (Treat pouchitis);
EU - Orphan Drug (Treat pouchitis)
PartnerAtlantic Healthcare plc

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