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AKCEA-APO(a)-LRx, IONIS-APO(a)-LRx (formerly ISIS-APO(a)-LRx)

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Company Ionis Pharmaceuticals Inc.
DescriptionLigand conjugated antisense version of ISIS-APO(a)Rx, an antisense oligonucleotide that inhibits apolipoprotein A
Molecular Target Apolipoprotein A-1 (APOA1) (apo(a))
Mechanism of ActionAntisense therapy
Therapeutic ModalityNucleic acid: Linear RNA: Antisense
Latest Stage of DevelopmentPhase I/II
Standard Indication Cardiovascular (unspecified)
Indication DetailsReduce elevated lipoprotein(a) (LPA) levels
Regulatory Designation

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