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Premiplex, mecasermin rinfabate (iPlex) (SHP607) (formerly HGT-ROP-001)

Also known as: Insulin-like growth factor-1/binding protein 3 (IGF-1/BP3) (formerly SomatoKine)

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Company Insmed Inc.
DescriptionComplex of insulin-like growth factor-1 (IGF-1) and its principal binding protein, IGF binding protein 3 (IGFBP3)
Molecular Target Insulin-like growth factor-1 (IGF-1) receptor (IGF1R) (CD221) ; Insulin-like growth factor (IGF) binding protein 3 (IGFBP3)
Mechanism of ActionInsulin-like growth factor-1 (IGF-1) receptor agonist
Therapeutic ModalityBiologic: Protein
Latest Stage of DevelopmentPhase II
Standard IndicationRetinopathy of prematurity
Indication DetailsPrevent retinopathy of prematurity (ROP); Treat retinopathy of prematurity (ROP)
Regulatory Designation U.S. - Fast Track (Treat retinopathy of prematurity (ROP));
U.S. - Orphan Drug (Treat retinopathy of prematurity (ROP));
EU - Orphan Drug (Treat retinopathy of prematurity (ROP))
PartnerShire plc

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