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Iclusig, ponatinib (formerly AP24534)

Also known as: 534

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Company Ariad Pharmaceuticals Inc.
DescriptionPan-BCR-ABL tyrosine kinase inhibitor (TKI)
Molecular Target BCR-ABL tyrosine kinase (BCR-ABL) ; FMS-like tyrosine kinase 3 (FLT3) (CD135)
Mechanism of ActionVascular endothelial growth factor (VEGF) inhibitor; BCR-ABL tyrosine kinase inhibitor; Tyrosine kinase receptor 2 (Tie2) inhibitor; Fibroblast growth factor (FGF) receptor (FGFR) antagonist
Therapeutic ModalitySmall molecule

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