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HGS-ETR1, mapatumumab

Also known as: TRAIL-R1 MAb

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Company GlaxoSmithKline plc
DescriptionTRM-1 antibody agonist of tumor necrosis factor (TNF)-related apoptosis-inducing ligand receptor 1 (TRAIL-R1)
Molecular Target Tumor necrosis factor (TNF) receptor superfamily member 10a (TNFRSF10A) (DR4) (TRAILR1) (CD261)
Mechanism of ActionBinds tumor necrosis factor-related apoptosis-inducing ligand receptor-1 (TRAIL-R1); Antibody
Therapeutic ModalityBiologic: Antibody
Latest Stage of DevelopmentPhase II
Standard IndicationLiver cancer
Indication DetailsTreat hepatocellular cancer (HCC)
Regulatory Designation
PartnerAstraZeneca plc

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