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Fovista, pegpleranib (formerly E10030)

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Company Ophthotech Corp.
DescriptionPegylated aptamer against platelet derived growth factor B (PDGFB; PDGF2)
Molecular Target Platelet derived growth factor B (PDGFB) (PDGF2)
Mechanism of Action 
Therapeutic ModalityNucleic acid: Aptamer
Latest Stage of DevelopmentPhase III
Standard IndicationAge-related macular degeneration (AMD)
Indication DetailsTreat age-related macular degeneration (AMD); Treat neovascular age-related macular degeneration (AMD); Treat wet age-related macular degeneration (AMD)
Regulatory Designation
PartnerGenentech Inc.;
Nektar Therapeutics;
Novartis AG

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