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Exalgo, Jurnista (NMED-1077) (formerly Oros hydromorphone)

Also known as: hydromorphone extended release tablets (formerly AP-77)

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Company Johnson & Johnson
DescriptionExtended-release formulation of hydromorphone hydrochloride
Molecular Target Mu opioid receptor (MOR) (OPRM1)
Mechanism of ActionMu opioid receptor agonist
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentMarketed
Standard IndicationPain
Indication DetailsManage moderate to severe pain in opoid-tolerant patients; Treat chronic osteoarthritis (OA) pain; Treat severe pain
Regulatory Designation


Epirus Biopharmaceuticals Inc.; Mallinckrodt plc

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