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Entresto, sacubitril/valsartan (LCZ696)

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Company Novartis AG
DescriptionCrystalline complex of valsartan, an antagonist of angiotensin II type 1 (AT1) receptor (ATGR1), and sacubitril, an inhibitor of neutral endopeptidase (neprilysin; MME; NEP; CD10), in an equimolar ratio
Molecular Target Angiotensin II type 1 (AT1) receptor (AGTR1) ; Neutral endopeptidase (neprilysin) (MME) (NEP) (CD10)
Mechanism of ActionNeutral endopeptidase inhibitor; Angiotensin II type 1 (AT1) receptor (ATGR1) antagonist
Therapeutic ModalitySmall molecule: Combination

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