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conjugated estrogens/bazedoxifene (CE/BZA) (Duavee, Duavive)

Also known as: Aprela, bazedoxifene CE, bazedoxifene/conjugated estrogens (BZA/CE)

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Company Ligand Pharmaceuticals Inc.
DescriptionTissue selective estrogen complex (TSEC) containing conjugated estrogens/bazedoxifene
Molecular Target Estrogen receptor
Mechanism of ActionSelective estrogen receptor modulator (SERM)
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentMarketed
Standard IndicationMenopause
Indication DetailsTreat menopause-associated symptoms; Treat non-hysterectomized women with moderate to severe vasomotor symptoms (VMS) and vulvar and vaginal atrophy (VVA) associated with menopause and prevent postmenopausal osteoporosis; Treat non-hysterectomized women with moderate to severe vasomotor symptoms (VMS) associated with menopause and prevent postmenopausal osteoporosis; Treat vasomotor symptoms
Regulatory Designation

U.S. - Standard Review (Treat non-hysterectomized women with moderate to severe vasomotor symptoms (VMS) and vulvar and vaginal atrophy (VVA) associated with menopause and prevent postmenopausal osteoporosis);
EU - Standard Review (Treat menopause-associated symptoms)

Partner

Pfizer Inc.


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