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Duavee, Duavive, conjugated estrogens/bazedoxifene (CE/BZA)

Also known as: Aprela, bazedoxifene CE, bazedoxifene/conjugated estrogens (BZA/CE)

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Company Ligand Pharmaceuticals Inc.
DescriptionCombination of bazedoxifene, a selective estrogen receptor modulator (SERM), and conjugated estrogens
Molecular Target Estrogen receptor 1 (ESR1)
Mechanism of ActionSelective estrogen receptor modulator (SERM)
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentMarketed
Standard IndicationMenopause
Indication DetailsTreat estrogen deficiency symptoms in postmenopausal women with a uterus; Treat menopause-associated symptoms; Treat non-hysterectomized women with moderate to severe vasomotor symptoms (VMS) and vulvar and vaginal atrophy (VVA) associated with menopause and prevent postmenopausal osteoporosis; Treat non-hysterectomized women with moderate to severe vasomotor symptoms (VMS) associated with menopause and prevent postmenopausal osteoporosis; Treat vasomotor symptoms
Regulatory Designation U.S. - Standard Review (Treat non-hysterectomized women with moderate to severe vasomotor symptoms (VMS) and vulvar and vaginal atrophy (VVA) associated with menopause and prevent postmenopausal osteoporosis);
EU - Standard Review (Treat menopause-associated symptoms)
PartnerPfizer Inc.

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