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Duavee, Duavive, conjugated estrogens/bazedoxifene (CE/BZA)

Also known as: Aprela, bazedoxifene CE, bazedoxifene/conjugated estrogens (BZA/CE)

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Company Ligand Pharmaceuticals Inc.
DescriptionCombination of bazedoxifene, a selective estrogen receptor modulator (SERM), and conjugated estrogens
Molecular Target Estrogen receptor (ESR1)
Mechanism of ActionSelective estrogen receptor modulator (SERM)
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentMarketed
Standard IndicationMenopause
Indication DetailsTreat estrogen deficiency symptoms in postmenopausal women with a uterus; Treat menopause-associated symptoms; Treat non-hysterectomized women with moderate to severe vasomotor symptoms (VMS) and vulvar and vaginal atrophy (VVA) associated with menopause and prevent postmenopausal osteoporosis; Treat non-hysterectomized women with moderate to severe vasomotor symptoms (VMS) associated with menopause and prevent postmenopausal osteoporosis; Treat vasomotor symptoms
Regulatory Designation U.S. - Standard Review (Treat non-hysterectomized women with moderate to severe vasomotor symptoms (VMS) and vulvar and vaginal atrophy (VVA) associated with menopause and prevent postmenopausal osteoporosis);
EU - Standard Review (Treat menopause-associated symptoms)
Partner Pfizer Inc.

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