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defibrotide (Defitelio)

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Company Jazz Pharmaceuticals plc
DescriptionSingle-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA
Molecular Target Cathepsin G (CTSG)
Mechanism of ActionCathepsin G inhibitor
Therapeutic ModalityNucleic acid: Linear DNA
Latest Stage of DevelopmentMarketed
Standard IndicationLiver disease
Indication DetailsPrevent hepatic veno-occlusive disease (VOD); Prevent pediatric veno-occlusive disease (VOD); Prevent veno-occlusive disease (VOD) in adults; Treat and prevent hepatic veno-occlusive disease (VOD); Treat and prevent hepatic veno-occlusive disease (VOD) in hematopoietic stem-cell transplantation therapy in adults and children; Treat hepatic veno-occlusive disease (VOD) in hematopoietic stem cell transplantation therapy in adults and children; Treat pediatric veno-occlusive disease (VOD); Treat severe veno-occlusive disease (VOD); Treat veno-occlusive disease (VOD)
Regulatory Designation U.S. - Expanded Access (Treat severe veno-occlusive disease (VOD));
U.S. - Fast Track (Prevent hepatic veno-occlusive disease (VOD));
U.S. - Orphan Drug (Treat and prevent hepatic veno-occlusive disease (VOD));
U.S. - Priority Review (Treat hepatic veno-occlusive disease (VOD) in hematopoietic stem cell transplantation therapy in adults and children);
EU - Orphan Drug (Treat and prevent hepatic veno-occlusive disease (VOD));
EU - Standard Review (Treat and prevent hepatic veno-occlusive disease (VOD) in hematopoietic stem-cell transplantation therapy in adults and children);
Australia - Orphan Drug (Treat severe veno-occlusive disease (VOD))
PartnerLink Healthcare;
Valeant Pharmaceuticals International Inc.

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Total Number of DealsTotal Deal ValueTotal Upfront CashTotal Milestone Payments

3

$1,149.4M

$1,034.5M

$85.1M


 Deals Details
DateCompanies InvolvedDeal HeadlineTotal Deal ValueTotal Upfront CashTotal Milestone
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