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bevenopran (formerly ADL5945, CB-5945, OpRA III)

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Company Eli Lilly and Co.
DescriptionMu opioid receptor (OPRM1; MOR) antagonist
Molecular Target Mu opioid receptor (MOR) (OPRM1)
Mechanism of ActionMu opioid receptor antagonist
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentPhase III
Standard IndicationConstipation
Indication DetailsTreat opioid-induced constipation (OIC)
Regulatory Designation
Partner Merck & Co. Inc.

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