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AXS-05

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Company Axsome Therapeutics Inc.
DescriptionDextromethorphan, an NMDA receptor antagonist, sigma-1 receptor agonist and inhibitor of serotonin and norepinephrine transporter, plus bupropion, a norepinephrine and dopamine reuptake inhibitor and nicotinic acetylcholine receptor (nAchR) antagonist
Molecular Target NMDA receptor ; Sigma-1 receptor
Mechanism of ActionNMDA receptor antagonist; Nicotinic acetylcholine receptor antagonist; Dopamine and norepinephrine reuptake inhibitor; Sigma-1 receptor agonist; Serotonin transporter (SERT) inhibitor; Norepinephrine transporter (NET) inhibitor
Therapeutic ModalitySmall molecule

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