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disodium zoledronate tetrahydrate (AXS-02)

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Company Axsome Therapeutics Inc.
DescriptionOral osteoclast inhibitor
Molecular Target Farnesyl diphosphate synthase (FDPS) (FPPS)
Mechanism of Action 
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentPhase III
Standard IndicationPain
Indication DetailsTreat chronic low back pain associated with Modic changes; Treat pain associated with complex regional pain syndrome (CRPS); Treat pain caused by osteoarthritis (OA) of the knee associated with bone marrow lesions
Regulatory Designation U.S. - Fast Track (Treat pain caused by osteoarthritis (OA) of the knee associated with bone marrow lesions);
U.S. - Fast Track (Treat pain associated with complex regional pain syndrome (CRPS));
U.S. - Orphan Drug (Treat pain associated with complex regional pain syndrome (CRPS));
EU - Orphan Drug (Treat pain associated with complex regional pain syndrome (CRPS))
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