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Ketas, ibudilast (AV411, MN-166)

Also known as: formerly AV-411

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Company Kyorin Pharmaceutical Co. Ltd.
DescriptionOral small molecule inhibitor of phosphodiesterase-4 (PDE-4), PDE-10 and macrophage migration inhibitory factor (MIF) that suppresses pro-inflammatory cytokines
Molecular Target Phosphodiesterase-4 (PDE-4) ; Macrophage migration inhibitory factor (MIF)
Mechanism of ActionLeukotriene B4 receptor antagonist; Phosphodiesterase-4 (PDE-4) inhibitor; Tumor necrosis factor (TNF) alpha inhibitor; Nitric oxide (NO) synthase inhibitor
Therapeutic ModalitySmall molecule

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