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APD421 (formerly ACA1421)

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Company Acacia Pharma Ltd.
DescriptionIV formulation of amisulpride, an off-patent dopamine D2 and D3 receptor antagonist
Molecular Target Dopamine D2 receptor ; Dopamine D3 receptor (DRD3)
Mechanism of Action 
Therapeutic Modality 
Latest Stage of DevelopmentPhase III
Standard IndicationEmesis
Indication DetailsPrevent cisplatin-induced vomiting; Prevent post-operative nausea and vomiting (PONV); Treat and prevent chemotherapy-induced nausea & vomiting (CINV) in cancer patients receiving cisplatin
Regulatory Designation


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