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Brigatinib (AP26113)

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Company Ariad Pharmaceuticals Inc.
DescriptionDual inhibitor of anaplastic lymphoma kinase (ALK) and EGFR
Molecular Target Anaplastic lymphoma kinase (ALK) ; Epidermal growth factor receptor (EGFR)
Mechanism of ActionAnaplastic lymphoma kinase (ALK) inhibitor; Epidermal growth factor (EGF) receptor inhibitor
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentPhase II
Standard IndicationNon-small cell lung cancer (NSCLC)
Indication DetailsTreat ALK-positive non-small cell lung cancer (NSCLC); Treat anaplastic lymphoma kinase (ALK)-positive, metastatic non-small cell lung cancer (NSCLC) in patients who are resistant to crizotinib; Treat non-small cell lung cancer (NSCLC)
Regulatory Designation

U.S. - Breakthrough Therapy (Treat anaplastic lymphoma kinase (ALK)-positive, metastatic non-small cell lung cancer (NSCLC) in patients who are resistant to crizotinib)

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