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motesanib diphosphate (AMG 706)

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Company Amgen Inc.
DescriptionSmall molecule antagonist of VEGF receptors 1, 2 and 3, platelet derived growth factor receptor (PDGFR) and c-Kit
Molecular Target Vascular endothelial growth factor (VEGF) receptor ; Stem cell factor (SCF) receptor tyrosine kinase (c-Kit) (KIT) (CD117)
Mechanism of ActionPlatelet derived growth factor receptor (PDGFR) kinase inhibitor
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentPhase III
Standard IndicationNon-small cell lung cancer (NSCLC)
Indication DetailsTreat advanced non-squamous non-small cell lung cancer; Treat non-small cell lung cancer (NSCLC)
Regulatory Designation
PartnerTakeda Pharmaceutical Co. Ltd.

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