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Amnolake, tamibarotene (formerly AM-80)

Also known as: Z-208 (formerly INNO-507, TM-411, TOS-80T)

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Collapse Summary General Information
Company CytRx Corp.
DescriptionSynthetic retinoid compound
Molecular Target Retinoic acid receptor alpha (RARA)
Mechanism of ActionRetinoic acid receptor (RAR) agonist
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentMarketed
Standard IndicationAcute promyelocytic leukemia (APL)
Indication DetailsTreat recurrent acute promyelocytic leukemia (APL); Treat relapsed or refractory acute promyelocytic leukemia (APL)
Regulatory Designation

U.S. - Fast Track (Treat relapsed or refractory acute promyelocytic leukemia (APL));
U.S. - Special Protocol Assessment (Treat relapsed or refractory acute promyelocytic leukemia (APL))

Partner

Lotus Pharmaceuticals Inc.; Nippon Shinyaku Co. Ltd.; TMRC Co. Ltd.


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