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Rintega, rindopepimut (CDX-110) (formerly PF-04948568)

Also known as: formerly ALT-110

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Company Celldex Therapeutics Inc.
DescriptionVaccine targeting EGFR variant III (EGFRvIII)
Molecular Target Epidermal growth factor variant III (EGFRvIII)
Mechanism of ActionVaccine
Therapeutic ModalityActive immunotherapy
Latest Stage of DevelopmentPhase III
Standard IndicationBrain cancer
Indication DetailsTreat EGFRvIII-positive glioblastoma multiforme (GBM) in adults; Treat EGFRvIII-positive recurrent glioblastoma; Treat glioblastoma; Treat glioblastoma multiforme (GBM); Treat malignant glioma; Treat newly diagnosed glioblastoma multiforme (GBM); Treat newly diagnosed, EGFRvIII-positive glioblastoma following surgical resection and chemoradiation
Regulatory Designation U.S. - Breakthrough Therapy (Treat EGFRvIII-positive glioblastoma multiforme (GBM) in adults);
EU - Orphan Drug (Treat glioblastoma);
EU - Orphan Drug (Treat glioblastoma multiforme (GBM))

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