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Baremsis, IV amisulpride (formerly ACA1421, APD421)

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Company Acacia Pharma Group plc
DescriptionLow-dose IV formulation of amisulpride, an off-patent dopamine D2 and D3 receptor (DRD3) antagonist
Molecular Target Dopamine D2 receptor ; Dopamine D3 receptor (DRD3)
Mechanism of ActionDopamine D2 receptor antagonist
Therapeutic ModalitySmall molecule
Latest Stage of DevelopmentPhase III
Standard IndicationEmesis
Indication DetailsPrevent cisplatin-induced vomiting; Prevent postoperative nausea and vomiting (PONV); Treat and prevent chemotherapy-induced nausea & vomiting (CINV) in cancer patients receiving cisplatin; Treat postoperative nausea and vomiting (PONV)
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