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ARTICLE | Translation in Brief

Cutting the net

Scientists link cholesterol to immune cell activation in atherosclerotic plaques

July 30, 2015 7:00 AM UTC

A pathway connecting cholesterol, neutrophils, and macrophages in atherosclerotic plaques could yield new targets for the disease.

While a group from the University of Virginia believes the role of immune cells in atherosclerotic plaques has been overstated (see Cover Story), another group at the Francis Crick Institute has found a link between cholesterol and immune cells in plaques that places the cells back in the center of the underlying plaque pathology. Inhibitors of the newly identified pathway could provide more tools for combating the disease...