Table 1. Trajectories of recipients of the California Institute for Quantitative Biosciences' (QB3) Bridging-the-Gap Awards.

Principal investigator

QB3 campus

Award year

Project

Status

Tejal Desai

University of California, San Francisco

2007

Microengineered particles for oral delivery of chemotherapeutics

Partnered and licensed technology to Zcube s.r.l., a unit of Zambon Co. S.p.A.

Michael Marletta

University of California, Berkeley

2007

Engineer H-NOX (heme nitric oxide/oxygen binding)-family proteins for therapeutic delivery of oxygen and nitric oxide

Founded Omniox Inc. in QB3 Garage and raised more than $4 million in Small Business Innovation Research (SBIR) funding

Amy Herr

UCBerkeley

2008

Rapid autoantibody profiling for systemic lupus erythematosus (SLE) using micro- and nanotechnology

Partnered and licensed technology to an undisclosed, international life sciences company

Brian Shoichet

UCSF

2009

Chemoinformatic and statistical methods to uncover links between drugs and the biological targets responsible for disease

Founded SeaChange Pharmaceuticals Inc. in QB3 Garage

Jim Wells

UCSF

2009

Apoptotic biomarkers for hematologic cancers

Unpartnered

Tejal Desai

UCSF

2009

Titania nonporous membranes for constant-rate interferon-α (IFNA; IFN-a) delivery to treat HCV

Founded Nano Precision Medical Inc. in QB3 Garage; now at QB3 East Bay Innovation Center

Charles Chiu

UCSF

2010

Pan-viral clinical diagnostic for respiratory and diarrheal illness

Partnered with Akonni Biosystems Inc.

Shuvo Roy

UCSF

2010

Wearable hemofiltration device for renal replacement

Forming startup

Holger Schmidt

University of California, Santa Cruz

2010

Portable, amplification-free virus detector using optofluidic chips

Founded LiquiLume Diagnostics Inc. at the San Jose BioCenter

Charles Craik

UCSF

2011

Noninvasive imaging of cancer by targeting active proteases and their receptors

Two industry partnerships under negotiation

Tejal Desai

UCSF

2011

Nanostructural biopolymer films for retinal drug delivery

Forming startup

John Kuriyan;
Art Weiss

UCBerkeley; UCSF

2011

Discover inhibitors of the catalytic activity of the T cell receptor (TCR) tyrosine kinase ZAP70 (z-chain (TCR) associated protein kinase 70 kDa)

Unpartnered

Adam Abate

UCSF

2012

Microfluidic device to analyze rare circulating tumor cells

Founded Torrent Bio Inc. in Redwood Shores, Calif.

Roger Linington;
Fitnat Yildiz

UCSC

2012

Biofilm inhibitors as therapeutics for surface-associated bacterial infection

Unpartnered

Trever Bivona

UCSF

2012

Systematic discovery of rational, molecularly targeted cancer polytherapies

Unpartnered; clinical trials starting

Matthew Jacobson; Scott Lokey

UCSF; UCSC

2012A

Discovery platform for orally bioavailable inhibitors of therapeutically relevant protein-protein interactions

Unpartnered

Shuvo Roy

UCSF

2012A

Intravascular capsule of pancreatic b islet cells to treat type 1 diabetes

Unpartnered

AFirst set of projects funded by the Johnson & Johnson Corporate Office of Science & Technology (COSAT).