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  • Tools & Techniques: Neutralizing the negatives of RNAi

    siRNN technology delivers RNAi to liver and other tissues

    The siRNN technology that Solstice licensed from UCSD could take RNAi-based therapies to tissues outside of the liver and expand their use to a host of new diseases

    Published on 12/18/2014
  • Genocea's mark on malaria

    Genocea has identified an immunological imprint in patients with malaria and is using a $1.2 million grant from the Gates Foundation to turn the findings into a vaccine.

    Published on 12/18/2014
  • Roche's heart for diabetes

    Roche scientists have developed a cell-based model of diabetic cardiomyopathy, but they say it is only step one en route to a system that properly represents ventricles of a diseased heart.

    Published on 12/4/2014
  • Figure 1: Paper-based diagnostic tests

    Tools: Paperback diagnostics Figure 1. Paper-based diagnostic tests. [a] A synthetic RNA switch is designed to detect a specific oligonucleotide sequence called trigger mRNA, which acts as a marker for a particular …

    Published on 11/20/2014
  • HemoShear's human touch

    HemoShear's in vitro tumor model shows a new application for its tissue modeling technology and could open it to business from oncology companies.

    Published on 11/20/2014
  • Paperback diagnostics

    A paper-based diagnostic using RNA switches could provide an easily distributed, rapid test for infectious diseases in point-of-care settings.

    Published on 11/20/2014
  • Box 1: Defined and virus free

    Tools: Building blood vessels Box 1. Defined and virus free. Researchers at the Houston Methodist Research Institute and Stanford University have published data in Circulation describing a viral vector-free …

    Published on 11/13/2014
  • Building blood vessels

    Indiana University researchers have found a route to building blood vessels by developing a protocol to generate mass quantities of endothelium-forming cells.

    Published on 11/13/2014
  • SQZ Biotech's main squeeze

    Two awards totaling over $300,000 will fuel SQZ Biotech's scale-up of its microfluidics-based CellSqueeze platform that delivers bioactive materials directly into cells.

    Published on 11/13/2014
  • Figure 1: Process for creating a 3D neuronal model of Alzheimer's disease

    Tools: AD goes 3D Figure 1. Process for creating a 3D neuronal model of Alzheimer's disease. [a] Human neuronal progenitor cells are transfected with lentivirus encoding mutant forms of amyloid precursor protein (APP…

    Published on 11/6/2014
  • AD goes 3D

    A 3D neuronal culture model of Alzheimer's disease is much improved over earlier models, but researchers disagree on whether it is close enough to human disease for use in drug discovery.

    Published on 11/6/2014
  • Sex matters at the NIH

    The NIH is taking steps to make the inclusion of both sexes in preclinical studies a standard practice.

    Published on 10/30/2014
  • Figure 1: CRISPR's double-edged knife

    Tools: Programmable sensitivity Figure 1. CRISPR's double-edged knife. Treatment of antibiotic-resistant bacteria with a clustered, regularly interspaced short palindromic repeats (CRISPR)-Cas9 agent yields different…

    Published on 10/23/2014
  • Programmable sensitivity

    CRISPR-based antimicrobials can resensitize antibiotic-resistant bacteria by targeting specific resistance genes and could add new tools for combating resistance.

    Published on 10/23/2014
  • A CRISPR possibility for DMD

    Findings that CRISPR-based genome editing can improve symptoms in a mouse model of Duchenne muscular dystrophy could lead to a therapeutic use of the technology, whose impact has thus far been as a research tool.

    Published on 10/2/2014
  • Figure 1: Biospleen design

    Tools: Bad blood Figure 1 Biospleen design. The biospleen fluidic device incorporates a high-flow vascular arterial channel, which is perfused with septic whole blood. That channel is interconnected by open slits to …

    Published on 9/18/2014
  • Bad blood

    Whereas pharmacological approaches to treat sepsis have languished in the clinic, a microfluidic device developed by a Massachusetts team cleanses pathogens and endotoxins from blood and increases survival in rat models…

    Published on 9/18/2014
  • Box 1: Cyclotide synthesis

    Tools: Circling back to basics Box 1. Cyclotide synthesis. Although synthetic macrocycle chemistry has been inspired by the study of natural products such as cyclosporine, the biosynthetic pathways for many …

    Published on 8/21/2014
  • Circling back to basics

    Creating potent and orally bioavailable macrocycles is more challenging than developing small molecules, but a trio of studies could close the gap by proposing new design guidelines, identifying protein-protein …

    Published on 8/21/2014
  • Figure 1: Liver preservation protocol

    Tools: Liver, supercooled Figure 1. Liver preservation protocol. The liver preservation protocol reported by Berendsen et al. combined subnormothermic machine perfusion (SNMP) with supercooling and enabled rat livers…

    Published on 8/14/2014
  • Liver, supercooled

    Harvard Medical School scientists have reported a method that triples the time rat livers can be preserved for transplant and could thus increase the number of donor organs available for patients. Spinout Organ …

    Published on 8/14/2014
  • Box 1: Specific BETs on remyelination

    Tools: High throughput remyelination Box 1. Specific BETs on remyelination A team at the Icahn School of Medicine at Mount Sinai has linked BET bromodomain protein-regulated gene transcription to oligodendrocyte …

    Published on 8/7/2014
  • Getting personal with CTCs

    Johnson & Johnson has licensed a technology that could personalize cancer treatment by using circulating tumor cells to screen for drug susceptibility and tumor mutations that evolve over time. But converting the method…

    Published on 8/7/2014
  • High throughput remyelination

    Remyelinating compounds have been difficult to identify in part because of a dearth of suitable high throughput screening platforms. UCSF researchers have now developed an assay that can identify active compounds and …

    Published on 8/7/2014
  • Regenerative light touch

    A Harvard University team has shown that low-power laser treatment could be used to noninvasively drive dental stem cell differentiation and tissue regeneration in rats. What remains to be determined is whether the …

    Published on 7/10/2014

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