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  • Figure: Next year in the clinic...

    On the road Tools & Techniques Next year in the clinic... In a Perspective in Science Translational Medicine, FDA outlined nine informatics research areas to advance regulatory evaluation of next-generation …

    Published on 4/21/2016
  • Sexy sequencing

    Just So Stories: How we got seduced into whole-genome sequencing

    Just So Stories: How we got seduced into whole-genome sequencing

    Published on 4/7/2016
  • Figure: A sequence in time

    Sexy sequencing Tools & Techniques A sequence in time DNA sequencing technologies have evolved since the Maxam-Gilbert technique of the 1970s, to today's automated high throughput methods . 1) Maxam-Gilbert …

    Published on 4/7/2016
  • Postmodern ART

    How HIV therapy is moving beyond ART

    A variety of strategies — from quarterly immunotherapies to single-dose gene therapies — aim to replace daily antiretroviral therapy for HIV.

    Published on 3/31/2016
  • Table: BioCentury Product Profile

    Shrinking reservoirs Tools & Techniques BioCentury Product Profile Biocentury Product Profile INNOVATION STAGE Product A recombinase or CRISPR-based gene-editing system that excises HIV provirus by targeting the…

    Published on 3/31/2016
  • Shrinking reservoirs

    Why attacking HIV reservoirs is a tall order

    Using an engineered recombinase or CRISPR to snip out the HIV genome, two groups think they can eliminate viral reservoirs. Reaching every cell will be the problem.

    Published on 3/31/2016
  • Figure: Gut move

    Gut re-action Tools & Techniques Gut move Researchers at Memorial Sloan Kettering Cancer Center (MSKCC) have developed a protocol to generate all the major cell types of the enteric nervous system from pluripotent …

    Published on 3/17/2016
  • Table: BioCentury Product Profile

    Gut re-action Tools & Techniques BioCentury Product Profile BioCentury Product Profile INNOVATION STAGE Product Patient-derived region-specific progenitor cells Concept A cell replacement therapy in which the …

    Published on 3/17/2016
  • Gut re-action

    Remaking the enteric nervous system

    A new method of turning human stem cells into gut neurons could provide the first non-surgical treatment for Hirschsprung's disease.

    Published on 3/17/2016
  • Ziopharm bets on the HLA-A odds

    The A & BCs of stem cell HLA editing

    By deleting HLA-A from hematopoietic stem cells, Ziopharm is increasing the chances of finding a donor match that stands to benefit minority patients in particular.

    Published on 3/10/2016
  • Figure: All together now

    -Omics overdrive Tools & Techniques All together now Global Genomics Group LLC (G3) is analyzing pan-omics measurements from its GLOBAL clinical study using GNS Healthcare Inc.'s Reverse Engineering and Forward …

    Published on 2/11/2016
  • Figure: Hearts exposed

    -Omics overdrive Tools & Techniques Hearts exposed In its GLOBAL clinical study, Global Genomics Group LLC acquired cardiac computed tomography (CT) images from 7,500 participants. Cardiac CT is a CAT scan adapted …

    Published on 2/11/2016
  • Table: -Omics R Us

    -Omics overdrive Tools & Techniques -Omics R Us Through its GLOBAL clinical study, Global Genomics Group LLC (G3) has accumulated genomic, epigenomic, transcriptomic, lipidomic, metabolomic and proteomic data for 7…

    Published on 2/11/2016
  • -Omics overdrive

    G3 uses six kinds of -omics and more to find targets

    Validation of its pan-omics analysis on a 7,500-subject database has netted Global Genomics Group a partnership with Sanofi, and a taste for more.

    Published on 2/11/2016
  • Animal detox

    NIH's Tox21 program reports progress on eliminating animal testing

    A rapid, large-scale screen from Tox21 meets NIH's goal of speeding up tox testing but is still a long way from the big mission of eliminating animals.

    Published on 2/11/2016
  • Figure: Switch it up

    Calibrating CARs Tools & Techniques Switch it up In two studies published in the Proceedings of the National Academy of Sciences, a team from the California Institute for Biomedical Research (Calibr) described a …

    Published on 2/4/2016
  • Table: CAR dashboards

    Calibrating CARs Tools & Techniques CAR dashboards At least seven companies are exploring molecular technologies to limit the activity of chimeric antigen receptor (CAR) T cells. The table highlights a select list …

    Published on 2/4/2016
  • Calibrating CARs

    Switchable CAR T cells could target solid tumors safely

    A tunable CAR T cell system relies on an antibody-based switch to dial down toxicity and could bypass healthy tissues well enough to use in solid tumors.

    Published on 2/4/2016
  • Figure: Don't grow up too fast

    Peer pressure Tools & Techniques Don't grow up too fast In a Journal of Clinical Investigation study, researchers from the National Cancer Institute (NCI) showed co-culture of naïve (light blue) and memory (dark …

    Published on 1/28/2016
  • Table: BioCentury Product Profile

    Peer pressure Tools & Techniques BioCentury Product Profile BIOCENTURY PRODUCT PROFILE INNOVATION STAGE Product Naïve T cells for adoptive immunotherapy Inhibitors of FASL signaling:(a) An anti-FASL mAb(b) A …

    Published on 1/28/2016
  • Peer pressure

    Shielding naïve T cells from older cells could improve adoptive immunotherapy

    Blocking "corrupting" signals between mature and naïve T cells during in vitro culture could improve the efficacy of adoptive immunotherapy.

    Published on 1/28/2016
  • Figure: Detect AND treat

    "And" not "or" in psoriasis Tools & Techniques Detect AND treat In a study in Science Translational Medicine, a group from ETH Zurich engineered a cell-based therapeutic that uses Boolean logic to promote secretion…

    Published on 1/14/2016
  • Table: Biocentury Product Profile

    "And" not "or" in psoriasis Tools & Techniques BIOCENTURY PRODUCT PROFILE INNOVATION STAGE Product Cytokine converter cells Concept Engineered cells that secrete anti-inflammatory cytokines only during flare-…

    Published on 1/14/2016
  • "And" not "or" in psoriasis

    Cytokine converter cells use Boolean logic to detect and treat psoriasis

    Programming implantable cells with Boolean logic could solve flare-up disease like psoriasis.

    Published on 1/14/2016
  • Figure: Encapsulation options

    Islets of hope Tools & Techniques Encapsulation options Protecting transplanted pancreatic cells from the immune system is one of the biggest challenges in developing cell therapies for diabetes. Two different …

    Published on 1/7/2016

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