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  • Cryo-EM a river

    As cryo-EM races forward, companies are partnering to keep up

    A rush of technical improvements are making cryo-EM an attractive choice for structure-based drug design, and companies are collaborating to catch the wave.

    Published on 7/14/2016
  • Box: New resolutions

    Cryo-EM a river Tools & Techniques New resolutions Fueled by technological improvements in cryo-electron microscopy (cryo-EM), a team at the National Cancer Institute (NCI) has been pushing the method's limitations…

    Published on 7/14/2016
  • Figure: Frozen in time

    Cryo-EM a river Tools & Techniques Frozen in time Researchers at the National Cancer Institute (NCI) have generated a composite image that illustrates how cryo-electron microscopy (cryo-EM) resolution has improved …

    Published on 7/14/2016
  • Figure: No entry

    Home is in the placenta Tools & Techniques No entry In a recent paper in Science Advances, a University of Manchester group found that a pair of tumor-targeting peptides can home to the placenta, without reaching …

    Published on 6/23/2016
  • Table: Preeclampsia pipeline

    Home is in the placenta Tools & Techniques Preeclampsia pipeline Select products in clinical and preclinical development to treat preeclampsia. At least five companies are developing therapeutics for preeclampsia, …

    Published on 6/23/2016
  • Home is in the placenta

    How tumor-targeting peptides could de-risk drug development in pregnancy

    The discovery of placenta-homing peptides that don't reach the fetus could shift the risk-reward ratio for drug development in pregnancy.

    Published on 6/23/2016
  • What GWAS will be

    Two studies help find which GWAS hits actually matter

    With a new way to identify the few functional genetic variants from thousands of hits, two groups have taken GWAS to the next level.

    Published on 6/23/2016
  • Figure: Massive screen of small changes

    What GWAS will be Tools & Techniques Massive screen of small changes Two groups from the Broad Institute of MIT and Harvard have published a pair of studies in Cell showing a massively parallel reporter assay (MPRA…

    Published on 6/23/2016
  • Figure: Massive screen of small changes

    What GWAS will be Tools & Techniques Massive screen of small changes Two groups from the Broad Institute of MIT and Harvard have published a pair of studies in Cell showing a massively parallel reporter assay (MPRA…

    Published on 6/23/2016
  • Figure: Massive screen of small changes

    What GWAS will be Tools & Techniques Massive screen of small changes Two groups from the Broad Institute of MIT and Harvard have published a pair of studies in Cell showing a massively parallel reporter assay (MPRA…

    Published on 6/23/2016
  • Figure: From red to green

    Building a better haystack Tools & Techniques From red to green Compounds generated by Macrolide Pharmaceuticals Inc.'s modular chemistry platform have shifted a heat map of antibacterial activity from poorly …

    Published on 6/9/2016
  • Figure: Modular macrocycles

    Building a better haystack Tools & Techniques Modular macrocycles Macrolide Pharmaceuticals Inc.'s modular chemistry platform uses eight modifiable molecular building blocks to construct complex macromolecular …

    Published on 6/9/2016
  • Table: BioCentury Product Profile

    Entrez LA Cell Tools & Techniques BioCentury Product Profile BioCentury Product Profile INNOVATION STAGE Product Chemically modified mAbs Concept Cell-permeable mAbs for targeting intracellular oncoproteins …

    Published on 6/9/2016
  • Building a better haystack

    How Macrolide's chemistry platform could accelerate antibiotics innovation

    Macrolide Pharmaceuticals unveils how its modular chemistry platform pumps out erythromycin analogs with greater speed and more structural diversity than has ever been possible before.

    Published on 6/9/2016
  • Entrez LA Cell

    LA Cell generates cell-penetrating antibodies to target intracellular proteins

    Sorrento formed the JV LA Cell with City of Hope to deliver antibodies to intracellular targets via a new cell-penetrating conjugation technology.

    Published on 6/9/2016
  • Figure: Lousy mouse

    Better dirty Tools & Techniques Lousy mouse A pair of studies published in Nature and Cell Host & Microbe introduce two different "dirty" mouse models to characterize how pathogen exposure shapes immune system …

    Published on 5/26/2016
  • Better dirty

    Getting the dirt on mouse models

    Two studies make the case that lab mice may have to get 'dirty' to be truly useful as immunotherapy models.

    Published on 5/26/2016
  • The long view

    Why lncRNA pioneer Jeannie Lee thinks the field is ripe for investment

    Long non-coding RNA pioneer Jeannie Lee thinks the modality's ability to up-regulate gene expression precisely and reversibly gives it a unique position in drug development.

    Published on 5/19/2016
  • Modeling with interference

    How marrying CRISPRi with iPS can produce better disease models

    By marrying CRISPRi with iPS cells, a UCSF team has created a scalable, widely applicable form of genetic knockdown for more - and better - models of disease.

    Published on 5/12/2016
  • Box: Knocking out or knocking down

    Modeling with interference Tools & Techniques Knocking out or knocking down CRISPRi's tunable and reversible gene knockdown makes it an ideal tool for modifications in induced pluripotent stem (iPS) cells, but it …

    Published on 5/12/2016
  • Figure: CRISPRi: Technological knockdown

    Modeling with interference Tools & Techniques CRISPRi: Technological knockdown In a new study in Cell Stem Cell, a group of University of California San Francisco researchers described how to use CRISPR …

    Published on 5/12/2016
  • Figure: Masking mutations

    Cutting-edge advances Tools & Techniques Masking mutations Researchers from The Rockefeller University presented a modification to traditional CRISPR-Cas9 technology that enables more accurate insertion of genetic …

    Published on 5/5/2016
  • Cutting-edge advances

    How two new techniques could make correcting genes with CRISPR easier

    Two studies from Harvard and Rockefeller have produced methods that expand the CRISPR toolbox to correct genes - rather than just disrupt them - more accurately.

    Published on 5/5/2016
  • On the road

    Nine challenges FDA wants scientists to solve for NGS-based diagnostics

    FDA has responded to the explosion of interest in next-generation sequencing for precision diagnostics with a roadmap for solving the big regulatory challenges.

    Published on 4/21/2016
  • Figure: Next year in the clinic...

    On the road Tools & Techniques Next year in the clinic... In a Perspective in Science Translational Medicine, FDA outlined nine informatics research areas to advance regulatory evaluation of next-generation …

    Published on 4/21/2016

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