Thursday, April 10, 2014
new tool for in vivo detection of liver toxicity could represent a
significant improvement over routine methods that only work in vitro or
on tissue slices.1 The litmus test for the Stanford University inventors will be
to show that the nanoparticle-based method can detect toxicity in compounds
that previously eluded standard analysis and later failed in the clinic.
drug-induced toxicity occurs primarily in the liver, Rao's team focused on
reactive metabolites formed as transient by-products of hepatic clearance
Rao told SciBX that the team is testing the
technology on a range of molecules in animals. He also plans to develop it for
clinical use, in particular for monitoring liver damage in patients waiting to
Fishburn, C.S. SciBX
Published online April 10, 2014
1. Shuhendler, A.J. et al. Nat. Biotechnol.; published
online March 23, 2014; doi:10.1038/nbt.2838
Contact: Jianghong Rao, Stanford University School of
Medicine, Stanford, Calif.
2. Kola, I. & Landis, J. Nat. Rev. Drug Discov. 3,
AND INSTITUTIONS mentioned
Intuitive Surgical Inc. (NASDAQ:ISRG) Sunnyvale, Calif.
NonClinical Safety Assessment, Mountain View, Calif.
(NYSE:PKI), Waltham, Mass.
Stanford University, Stanford, Calif.
Stanford University School of Medicine, Stanford, Calif.
University of Toronto, Toronto, Ontario, Canada