Thursday, February 27, 2014
Academics and companies alike are scrambling-and thus far
failing-to reproduce a surprisingly simple method for generating pluripotent
mouse stem cells that uses an external stress stimulus to trigger
reprogramming. Whether the method simply does not work or just faces initial
hurdles similar to those experienced by other induced pluripotent stem cell-generating
technologies remains to be seen.
after publication, other researchers raised questions related to the data
reported in the papers and the overall reproducibility of the method of
generating STAP cells. RIKEN and Nature have launched investigations.
if the reproducibility issue is laid to rest, there needs to be more research
on the molecular and cellular mechanisms that initiate the transition to STAP
cells and on the epigenetic state of the STAP cells.
B. SciBX 7(8); doi:10.1038/scibx.2014.218 Published online Feb. 27, 2014
1. Obokata, H. et al.
Nature; published online Jan. 29, 2014; doi:10.1038/nature12968 Contact:
Charles A. Vacanti, Harvard Medical School, Boston, Mass. e-mail: firstname.lastname@example.org
Contact: Haruko Obokata, RIKEN Center for Developmental Biology, Kobe,
Japan e-mail: email@example.com
2. Takahashi, K. &
Yamanaka, S. Cell 126, 663-676 (2006)
3. Hou, P. et al.
Science 341, 651-654 (2013)
4. Thorpe, T.A. Mol.
Biotechnol. 37, 169-180 (2007)
5. Obokata, H. et al.
Nature 505, 676-680 (2014)
6. Abad, M. et al.
Nature 502, 340-345 (2013)
AND INSTITUTIONS MENTIONED
Advanced Cell Technology Inc. (OTCBB:ACTC), Santa Monica, Calif.
Brigham and Women's Hospital, Boston, Mass.
California Stem Cell Inc., Irvine, Calif.
Cellular Dynamics International Inc. (NASDAQ:ICEL), Madison, Wis.
Harvard Medical School, Boston, Mass.
MRC Centre for Regenerative Medicine, Edinburgh, U.K.
RIKEN Center for Developmental Biology, Kobe, Japan
Spanish National Cancer Research Centre, Madrid, Spain
Weizmann Institute of Science, Tel Aviv, Israel