Family seeds

It has been long assumed that the specificity of microRNA inhibitors is determined by length-dogma held that anti-miRNAs should be more than 16 nucleotides and approximate the length of the actual miRNA targets. Now, an international team has in vivo proof of concept that using anti-miRNAs of only eight nucleotides in length does not compromise selectivity and provides a simple tool for blocking multiple miRNAs at once.¹

The researchers are planning a Phase I trial following additional toxicology studies in animals...