Figure 1. Anti-miRNA delivery by B cells. Almanza et al. have engineered B cells to deliver anti-microRNA to other immune cells. The findings suggest a new avenue for delivering therapeutic miRNA.

A plasmid (a) engineered to encode a short sequence complementary to microRNA-150 (anti-miR-150) is transfected in murine
B cells (b). In cell culture and in vivo, engineered B cells interact with T cells, which naturally express miR-150 (c). When B cells and T cells interact to form an immunological synapse (d), anti-miR-150 is secreted into membrane-bound extracellular vesicles (exosomes), which are absorbed by the T cells (e). This leads to degradation and knockdown of endogenous miR-150 (f).