BioCentury
ARTICLE | Tools & Techniques

Crisper results for CRISPR

September 12, 2013 7:00 AM UTC

Since its introduction earlier this year, proponents of CRISPR-based genome editing have touted its simplicity and efficiency over other genome editing platforms, but they have more recently also offered a word of caution on its specificity.1-3 Research from the Broad Institute of MIT and Harvard may now allay these concerns with an updated version of the technique that decreases editing activity at predicted off-target sites by 50- to 1,000-fold compared with earlier implementations.4

The group now needs to assess the approach's off-target editing activity on the whole-genome level...