Thursday, May 23, 2013
A North Carolina team has shown that fetal deficiency in adrenomedullin
resulted in mouse placental abnormalities similar to those found in
preeclampsia, thereby underscoring adrenomedullin's potential as a marker for
the indication.1 Future studies will need to replicate the findings
in other animal models and determine whether low adrenomedullin levels are
found in all preeclampsia cases or just a subset.
M.J. SciBX 6(20);
Published online May 23, 2013
1. Li, M. et al. J. Clin. Invest.; published
online May 1, 2013; doi:10.1172/JCI67039
Contact: Kathleen M. Caron, The
University of North Carolina at Chapel Hill School of Medicine, Chapel
2. Witlin, A. et al.
Biol. Reprod. 67, 1025-1031 (2002)
3. Ross, G.R. &
Yallampalli, C. Biol. Reprod. 76, 118-123 (2007)
4. Lenhart, P.M. &
Caron, K.M. Trends Endocrinol. Metab. 23, 524-532 (2012)
5. Li, M. et al. J.
Clin. Invest. 116, 2653-2662 (2006)
6. Li, M. et al. Biol.
Reprod. 79, 1169-1175 (2008)
AND INSTITUTIONS MENTIONED
Duke University Medical Center, Durham, N.C.
Glenveigh Medical LLC, Chattanooga, Tenn.
Thermo Fisher Scientific Inc. (NYSE:TMO), Waltham, Mass.
The University of North Carolina at Chapel Hill, Chapel Hill, N.C.
The University of North Carolina at Chapel Hill School of
Medicine, Chapel Hill,
The University of Tennessee College of Medicine Chattanooga, Chattanooga, Tenn.