Thursday, February 7, 2013
Researchers from The University of Texas at Austin have
developed a high throughput method for sequencing individual B cell
immunoglobulin receptors that keeps the link between their paired heavy and
light variable chains intact.1 The technique increases the
efficiency of identifying disease biomarkers and designing therapeutic
antibodies but requires modifications to increase throughput and accuracy.
This single-cell method not only could help sequence B cells
more accurately than traditional high throughput approaches but also should
offer cost and speed advantages over other single-cell sequencing methods.
Martz, L. SciBX 6(5); doi:10.1038/scibx.2013.108 Published Feb. 7, 2013
1. DeKosky, B.J. et al.
Nat. Biotechnol.; published online Jan. 20, 2013; doi:10.1038/nbt.2492 Contact:
George Georgiou, The University of Texas at Austin, Austin, Texas e-mail: email@example.com
AND INSTITUTIONS MENTIONED
Ablynx N.V. (Euronext:ABLX),
Adaptive Biotechnologies Corp., Seattle, Wash.
Atreca Inc., San
Charité University Medicine, Berlin, Germany
German Rheumatism Research Center, Berlin, Germany
Illumina Inc. (NASDAQ:ILMN), San Diego, Calif.
Stanford University School of Medicine, Stanford, Calif.
The University of Chicago, Chicago, Ill.
University of Houston, Houston, Texas
The University of Texas at Austin, Austin, Texas