Thursday, October 25, 2012
Duke University School of Medicine researchers have developed a way to grow large
quantities of regulatory B cells.1 The team used an infusion of Breg
cells to suppress a murine form of multiple sclerosis and now wants to test the
immunomodulatory cells in other autoimmune diseases. They are hoping to launch
a company based on the technology.
Isolate and activate
The team began by purifying general B
cell precursors from the spleens of mice and treating them in vitro with
a range of cytokines suspected to influence Breg cell development.
Tedder thinks infusions of large
numbers of patient-derived, ex vivo-
activated Breg cells could help to rapidly shut down autoimmune
Osherovich, L. SciBX 5(42); doi:10.1038/scibx.2012.1103
Published online Oct. 25, 2012
1. Yoshizaki, A. et al.
Nature; published online Oct. 14, 2012; doi:10.1038/nature11501
Contact: Thomas F. Tedder, Duke University School of Medicine, Durham,
2. Osherovich, L. SciBX
3. Yanaba, K. et al.
Immunity 28, 639-650 (2008)
4. Saggoo, P. et al.
Sci. Transl. Med. 3, 83ra42 (2011)
5. Feng, G. et al. Sci.
Transl. Med. 3, 83ra40 (2011)
6. Hippen, K.L. et al.
Sci. Transl. Med. 3, 83ra41 (2011)
7. Osherovich, L. SciBX
AND INSTITUTIONS MENTIONED
Duke University School of Medicine, Durham, N.C.
Thomas Jefferson University, Philadelphia, Pa.