Figure 1: Nkg2d ligands contribute to the synergy of radiotherapy and anti-CTLA-4 mAbs
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Thursday, September 20, 2012
Figure 1. Nkg2d ligands contribute to the synergy of radiotherapy and
anti-CTLA-4 mAbs. In mice with poorly immunogenic murine carcinoma cells
treated with an anti-CTLA-4 (CD152) antibody,
infiltrating cytolytic T cells did not form stable interactions with tumor
cells (I). Radiotherapy promoted stable interactions and tumor cell
elimination by inducing retinoic acid early inducible-1
(Rae-1) on tumor cells
(II). The interaction of Rae-1 on tumor cells with Nkg2d (killer cell lectin-like receptor
subfamily K member 1; Klrk1; Cd314) on infiltrating
T cells was required for antitumor activity in mice treated with the anti-CTLA-4
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