Thursday, June 7, 2012
Figure 1. Brain on the battlefield. Research published in Science
Translational Medicine by
scientists at the Boston University School of Medicine
has shown that a single concussive air blast is sufficient to generate signs of
chronic traumatic encephalopathy (CTE) in mice.
was designed to mimic the situation of a soldier experiencing a shock wave from
a nearby bomb blast on a battlefield.
the blast did not kill the mouse [a], it generated enough force to accelerate the mouse's
head [b] and
cause phosphorylation of microtubule-associated protein-t (MAPT; TAU; FTDP-17) as well as damage at the cellular
including neuroinflammation and neurodegeneration [f,g]. That damage was associated with
significant cognitive impairment [h,i], a hallmark of CTE.