BioCentury
ARTICLE | Tools & Techniques

T cell prognosis for IBD

October 27, 2011 7:00 AM UTC

A U.K. team has identified a prognostic gene expression signature in CD8+ T cells that could be used to guide treatment decisions in patients with inflammatory bowel disease.1 The researchers are now planning a prospective clinical trial to verify the validity and utility of the signature.

IBD is an autoinflammatory condition that encompasses Crohn's disease (CD) and ulcerative colitis (UC), which have a related etiology but distinct clinical presentation. Treating UC and CD is complicated because clinical symptoms do not effectively predict the extent of disease progression...