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  • The long view

    Why lncRNA pioneer Jeannie Lee thinks the field is ripe for investment

    Long non-coding RNA pioneer Jeannie Lee thinks the modality's ability to up-regulate gene expression precisely and reversibly gives it a unique position in drug development.

    Published on 5/19/2016
  • Modeling with interference

    How marrying CRISPRi with iPS can produce better disease models

    By marrying CRISPRi with iPS cells, a UCSF team has created a scalable, widely applicable form of genetic knockdown for more - and better - models of disease.

    Published on 5/12/2016
  • Box: Knocking out or knocking down

    Modeling with interference Tools & Techniques Knocking out or knocking down CRISPRi's tunable and reversible gene knockdown makes it an ideal tool for modifications in induced pluripotent stem (iPS) cells, but it …

    Published on 5/12/2016
  • Figure: CRISPRi: Technological knockdown

    Modeling with interference Tools & Techniques CRISPRi: Technological knockdown In a new study in Cell Stem Cell, a group of University of California San Francisco researchers described how to use CRISPR …

    Published on 5/12/2016
  • Figure: Masking mutations

    Cutting-edge advances Tools & Techniques Masking mutations Researchers from The Rockefeller University presented a modification to traditional CRISPR-Cas9 technology that enables more accurate insertion of genetic …

    Published on 5/5/2016
  • Cutting-edge advances

    How two new techniques could make correcting genes with CRISPR easier

    Two studies from Harvard and Rockefeller have produced methods that expand the CRISPR toolbox to correct genes - rather than just disrupt them - more accurately.

    Published on 5/5/2016
  • On the road

    Nine challenges FDA wants scientists to solve for NGS-based diagnostics

    FDA has responded to the explosion of interest in next-generation sequencing for precision diagnostics with a roadmap for solving the big regulatory challenges.

    Published on 4/21/2016
  • Figure: Next year in the clinic...

    On the road Tools & Techniques Next year in the clinic... In a Perspective in Science Translational Medicine, FDA outlined nine informatics research areas to advance regulatory evaluation of next-generation …

    Published on 4/21/2016
  • Sexy sequencing

    Just So Stories: How we got seduced into whole-genome sequencing

    Just So Stories: How we got seduced into whole-genome sequencing

    Published on 4/7/2016
  • Figure: A sequence in time

    Sexy sequencing Tools & Techniques A sequence in time DNA sequencing technologies have evolved since the Maxam-Gilbert technique of the 1970s, to today's automated high throughput methods . 1) Maxam-Gilbert …

    Published on 4/7/2016
  • Postmodern ART

    How HIV therapy is moving beyond ART

    A variety of strategies — from quarterly immunotherapies to single-dose gene therapies — aim to replace daily antiretroviral therapy for HIV.

    Published on 3/31/2016
  • Table: BioCentury Product Profile

    Shrinking reservoirs Tools & Techniques BioCentury Product Profile Biocentury Product Profile INNOVATION STAGE Product A recombinase or CRISPR-based gene-editing system that excises HIV provirus by targeting the…

    Published on 3/31/2016
  • Shrinking reservoirs

    Why attacking HIV reservoirs is a tall order

    Using an engineered recombinase or CRISPR to snip out the HIV genome, two groups think they can eliminate viral reservoirs. Reaching every cell will be the problem.

    Published on 3/31/2016
  • Figure: Gut move

    Gut re-action Tools & Techniques Gut move Researchers at Memorial Sloan Kettering Cancer Center (MSKCC) have developed a protocol to generate all the major cell types of the enteric nervous system from pluripotent …

    Published on 3/17/2016
  • Table: BioCentury Product Profile

    Gut re-action Tools & Techniques BioCentury Product Profile BioCentury Product Profile INNOVATION STAGE Product Patient-derived region-specific progenitor cells Concept A cell replacement therapy in which the …

    Published on 3/17/2016
  • Gut re-action

    Remaking the enteric nervous system

    A new method of turning human stem cells into gut neurons could provide the first non-surgical treatment for Hirschsprung's disease.

    Published on 3/17/2016
  • Ziopharm bets on the HLA-A odds

    The A & BCs of stem cell HLA editing

    By deleting HLA-A from hematopoietic stem cells, Ziopharm is increasing the chances of finding a donor match that stands to benefit minority patients in particular.

    Published on 3/10/2016
  • Figure: All together now

    -Omics overdrive Tools & Techniques All together now Global Genomics Group LLC (G3) is analyzing pan-omics measurements from its GLOBAL clinical study using GNS Healthcare Inc.'s Reverse Engineering and Forward …

    Published on 2/11/2016
  • Figure: Hearts exposed

    -Omics overdrive Tools & Techniques Hearts exposed In its GLOBAL clinical study, Global Genomics Group LLC acquired cardiac computed tomography (CT) images from 7,500 participants. Cardiac CT is a CAT scan adapted …

    Published on 2/11/2016
  • Table: -Omics R Us

    -Omics overdrive Tools & Techniques -Omics R Us Through its GLOBAL clinical study, Global Genomics Group LLC (G3) has accumulated genomic, epigenomic, transcriptomic, lipidomic, metabolomic and proteomic data for 7…

    Published on 2/11/2016
  • -Omics overdrive

    G3 uses six kinds of -omics and more to find targets

    Validation of its pan-omics analysis on a 7,500-subject database has netted Global Genomics Group a partnership with Sanofi, and a taste for more.

    Published on 2/11/2016
  • Animal detox

    NIH's Tox21 program reports progress on eliminating animal testing

    A rapid, large-scale screen from Tox21 meets NIH's goal of speeding up tox testing but is still a long way from the big mission of eliminating animals.

    Published on 2/11/2016
  • Figure: Switch it up

    Calibrating CARs Tools & Techniques Switch it up In two studies published in the Proceedings of the National Academy of Sciences, a team from the California Institute for Biomedical Research (Calibr) described a …

    Published on 2/4/2016
  • Table: CAR dashboards

    Calibrating CARs Tools & Techniques CAR dashboards At least seven companies are exploring molecular technologies to limit the activity of chimeric antigen receptor (CAR) T cells. The table highlights a select list …

    Published on 2/4/2016
  • Calibrating CARs

    Switchable CAR T cells could target solid tumors safely

    A tunable CAR T cell system relies on an antibody-based switch to dial down toxicity and could bypass healthy tissues well enough to use in solid tumors.

    Published on 2/4/2016

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