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Chronological Index of : Therapeutics

 Current Issue
  • Therapeutics: Wnt pathway; wingless-type MMTV integration site family member 3A (WNT3A)

    INDICATION: Breast cancer; cancer In vitro and mouse studies identified an inhibitor of WNT3A palmitoylation that could help treat Wnt pathway-driven breast and other cancers. Cell-based screening in human cell-based…

    Published on 8/20/2015
  • Therapeutics: Zaire ebolavirus glycoprotein

    INDICATION: Ebola In vivo studies suggest an aerosolized vaccine could help treat Ebola. In macaques, aerosol delivery of a vector-based vaccine encoding Zaire ebolavirus glycoprotein into the respiratory tract …

    Published on 8/20/2015
  • Therapeutics: ATG7 autophagy related 7 homolog (ATG7)

    INDICATION: Colorectal cancer Mouse studies suggest inhibiting ATG7 while maintaining commensal gut bacteria could help prevent colorectal cancer. In a mouse model of spontaneous colorectal cancer, ATG7 knockout in …

    Published on 8/13/2015
  • Therapeutics: Cathepsin B; cathepsin L (CTSL); α-synuclein (SNCA)

    INDICATION: Parkinson's disease (PD) In vitro studies suggest activating cathepsin L and cathepsin B could help treat PD. In lysosomal extracts from mouse liver and brain cells, cathepsin L and cathepsin B cleaved …

    Published on 8/13/2015
  • Therapeutics: Crystallin α A (CRYAA; HSPB4); lanosterol synthase (LSS)

    INDICATION: Cataract In vitro and dog studies suggest the steroid precursor lanosterol could help treat cataracts caused by aggregation of CRYAA and other crystallin proteins in lens fibers. In human lens progenitor …

    Published on 8/13/2015
  • Therapeutics: Dengue virus envelope protein E (DENV_gp1)

    INDICATION: Dengue fever; viral infection Mouse studies suggest intramuscular delivery of DNA vectors encoding human neutralizing antibodies could help prevent dengue fever and viral infections. A DNA vector was …

    Published on 8/13/2015
  • Therapeutics: Dopamine D3 receptor (DRD3)

    INDICATION: Addiction In vitro and mouse studies suggest phenylpiperazine-based DRD3 antagonists could help treat heroin addiction. Chemical synthesis and testing in a cell-based assay of DRD3-dependent mitogenesis …

    Published on 8/13/2015
  • Therapeutics: Dystrophin (DMD)

    INDICATION: Enterovirus Mouse studies suggest reducing levels of an enteroviral C-terminal cleavage product of DMD relative to full-length DMD could help treat the cardiopathology of enterovirus infection. In mice, …

    Published on 8/13/2015
  • Therapeutics: Eukaryotic translation initiation factor 4E (eIF4E)

    INDICATION: Cancer Cell culture and mouse studies suggest inhibiting eIF4E could help treat cancer. In mouse embryonic fibroblasts transformed with oncogenes, heterozygous knockout of eIF4E increased intracellular …

    Published on 8/13/2015
  • Therapeutics: FK506 binding protein 1B 1 (FKBP1B; calstabin-2)

    INDICATION: Cognitive dysfunction Rat studies suggest FKBP1B could help treat age-related cognitive dysfunction. In aged rats, vector-mediated expression of FKBP1B in the hippocampus decreased calcium-dependent …

    Published on 8/13/2015
  • Therapeutics: G protein-coupled receptor 174 (GPR174)

    INDICATION: Multiple sclerosis (MS) Studies in mice suggest inhibiting GPR174 could help treat MS and other autoimmune diseases. In normal mice, GPR174 levels were higher in mature T regulatory cells (Tregs) than in …

    Published on 8/13/2015
  • Therapeutics: HECT domain containing E3 ubiquitin protein ligase 2 (HECTD2)

    INDICATION: Inflammation; pulmonary Mouse studies suggest inhibiting HECTD2 could help treat lung inflammation. In a mouse model of pneumonia, pretreatment with a lentiviral vector encoding HECTD2 increased lung …

    Published on 8/13/2015
  • Therapeutics: Interleukin-21 (IL-21)

    INDICATION: HIV / AIDS In vitro and mouse studies suggest IL-21 could help treat the early stages of HIV infection. In cultures of primary human lymphoid aggregates challenged with HIV-1 isolates, pretreatment with …

    Published on 8/13/2015
  • Therapeutics: LFA-1 (CD11a-CD18)

    INDICATION: Alzheimer's disease (AD) Mouse studies suggest temporary depletion of neutrophils or inhibition of the neutrophil-trafficking protein LFA-1 could help treat AD. In postmortem brains, neutrophil numbers …

    Published on 8/13/2015
  • Therapeutics: MicroRNA-194 (miR-194)

    INDICATION: Liver cancer In vitro, mouse and patient sample studies suggest miR-194 could help prevent metastasis of hepatocellular carcinoma (HCC). In tumor samples from HCC patients and five HCC cell lines, miR-194…

    Published on 8/13/2015
  • Therapeutics: Microtubule-associated protein τ (tau; MAPT; FTDP-17)

    INDICATION: Shock / trauma In vitro and mouse studies suggest inhibiting the cis isomer of phosphorylated tau (cis p-tau) could help prevent tauopathies following traumatic brain injury (TBI). In the brains of two …

    Published on 8/13/2015
  • Therapeutics: N-acylsphingosine amidohydrolase 1 (ASAH1)

    INDICATION: Hepatic Mouse studies suggest activating ASAH1 could help treat hepatic steatosis. In mouse models of diet-induced obesity, liver-specific overexpression of ASAH1 increased glucose tolerance and insulin …

    Published on 8/13/2015
  • Therapeutics: Transmembrane channel-like-1 (TMC1); TMC2

    INDICATION: Hearing loss Mouse studies suggest TMC1 or TMC2 gene therapy could help treat hearing loss caused by loss-of-function mutations in TMC1, whose functions in auditory signaling are redundant with TMC2. In …

    Published on 8/13/2015
  • Therapeutics: Chikungunya virus structural polyprotein (CHIKVgp2)

    INDICATION: Chikungunya virus Cell culture and mouse studies suggest broadly neutralizing antibodies (bNAbs) against the E2 protein component of CHIKVgp2 could help prevent or treat Chikungunya viral infection. …

    Published on 8/6/2015
  • Therapeutics: Coronavirus S protein

    INDICATION: Coronavirus Studies in cell lines and mice identified two mAbs that could help prevent or treat Middle East respiratory syndrome coronaviral (MERS-CoV) infection. Screening of antibodies from the spleens …

    Published on 8/6/2015
  • Therapeutics: Cysteine-rich angiogenic inducer 61 (CYR61; CCN1)

    INDICATION: Wounds Mouse studies suggest CYR61 could promote wound healing. Normal wound healing depends on CYR61-mediated recognition of apoptotic markers on neutrophils by integrin α5 (CD49e) on macrophages, …

    Published on 8/6/2015
  • Therapeutics: Death-associated protein kinase 1 (DAPK1; DAPK)

    INDICATION: Breast cancer In vitro and mouse studies suggest inhibiting DAPK1 could help treat p53-mutant, triple-negative breast cancer (TNBC). In p53-mutant TNBC cell lines, DAPK1 shRNA or a DAPK1 inhibitor …

    Published on 8/6/2015
  • Therapeutics: Dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN; CD209)

    INDICATION: Pulmonary fibrosis Mouse studies suggest activating DC-SIGN could help treat pulmonary fibrosis and other fibrotic diseases. In a mouse model of acute lung inflammation, a small molecule activator of DC-…

    Published on 8/6/2015
  • Therapeutics: DJ-1 (PARK7)

    INDICATION: Obesity Cell culture and mouse studies suggest inhibiting DJ-1 could help treat obesity. In mice, a high-fat diet increased muscle levels of DJ-1 mRNA compared with a normal diet. In cultured mouse …

    Published on 8/6/2015
  • Therapeutics: EPH receptor A2 (EPHA2)

    INDICATION: Cancer In vitro and mouse studies suggest conjugates of EPHA2-targeting peptidomimetics and paclitaxel could help treat EPHA2-positive cancers. EPHA2 expression in tumors is associated with increased …

    Published on 8/6/2015

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